Protease Responsive Nanogels for Transcytosis across the Blood−Brain Barrier and Intracellular Delivery of Radiopharmaceuticals to Brain Tumor Cells (Adv. Healthcare Mater. 20/2021)
نویسندگان
چکیده
Blood–Brain Barrier In article number 2100812 by Smriti Singh, Agnieszka Morgenroth, and co-workers, Matrix metalloprotease (MMP) sensitive nanogels are synthesized for effective delivery of a radiopharmaceutical ([125I]ITdU) across the blood-brain barrier (BBB). The show efficient transcytosis in vitro model BBB co-cultured with glioblastoma cells. Once transcytosed, degrade an up-regulated MMP2/9 environment release radiopharmaceutical, which gets incorporated into DNA tumor cells thymidine salvage pathway.
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ژورنال
عنوان ژورنال: Advanced Healthcare Materials
سال: 2021
ISSN: ['2192-2640', '2192-2659']
DOI: https://doi.org/10.1002/adhm.202170100